Anexo 1

Calculo estandarizacin
Para preparar 150 ml de MeONa
m=

0.1 eq/L x 0.150 L x 22.99 g/eq = 0.3449 g MeONa

masa patrn primario

m = 0.1 eq/ L x 0.012 L x 122.12 g/eq = 0.1465 g acido benzoico
Clculos Normalidad N = m/ Vx Peq
N1 = 0.1450 g / 0.0076 L x 122.12 g/eq = 0.1562 N
N2 = 0.1451 g / 0.0075 L x 122.12 g/eq = 0.1584 N
N3 = 0.1466 g / 0.0075 L x 122.12 g/eq = 0.160 N
N promedio = 0.1562 + 0.1584 + 0.160 / 3 = 0.158 N
CV = (1.89 x 10-3 / 0.158) x 100 = 1.21
Clculos valoracin
Masa acido benzoico
m = 0.0822 N x 0.012 L x 122.22 g/eq = 0.12045 g acido benzoico
Masa de cido acetilsaliclico contenido en las aspirinas
La etiqueta reporta 500 mg x tableta
4 tabletas = 2.4022 g = 2 g de cido acetilsaliclico
M = 0.1582 N x 0.015 L x 180.16 Eq/g = 0,4275 de cido acetilsaliclico
m1= 0.1582 N x 0.0147 L x 180.16g/eq = 0.4186 g
m2= 0.1582 N x 0.0148 L x 180.16 g/eq = 0.4218 g
m3= 0.1582 N x 0.0148 L x 180.16 g/eq = 0.4218 g
Calculo pureza
m = (0.4189 x 2.4022 / 0.5116 g) = 1.9612 g
m = (0.4218 x 2.4022 / 0.5142 g) = 1.9705 g
m = (0.4218 x 2.4022 / 0.5192 g) = 1.9516 g
%P1 = [(1,9612/ 4) x 100)/ 0.5] = 98.06 %
%P2 = [(1,9705/ 4) x 100)/ 0.5] = 98.52 %
%P3 = [(1,9516/ 4) x 100)/ 0.5] = 97.58 %
%P promedio = 98.15 %
CV = (0.502924 / 98.15) x 100 = 0,5124

Anexo 2
Clculos estudio terico
Inicio pH Acido dbil = (9.4) (log 0.01) = 5.7
APE pH buffer = 9.4 + log (0.5x0.01 / 0.01 x (1- 0.5)) = 9.4
PE pH base dbil = (16.9) + (9.4) + (log 0.01) = 12.15
DPE pH base fuerte = 16.9 + log (0.01 x (1.5 -1)) = 14.6
Base fuerte = 16.9+ log (0.01 x (2 -1)) = 14.9
Cuantitatividad = 10-9.4/ 10-16.9 = 107.5
%P = (1- 1/ (0.01 x 107.5) x 100 = 99.82 %

Vire del indicador

% error 0.01
0.00001

100 %
0.01 %

APE pH = 9.4 + log (0.5 x0.01 / 0.00001) = 12.09

DPE pH = 16.9 + log (0.00001) = 11.9