Insulina

Body cells take up more glucose.

Insulin Beta cells of pancreas release insulin into the blood. Liver takes up glucose and stores it as glycogen.

Blood glucose level declines.

STIMULUS: Blood glucose level rises (for instance, after eating a carbohydrate-rich meal).

Homeostasis: Blood glucose level (70110 mg/m100mL) STIMULUS: Blood glucose level falls (for instance, after skipping a meal).

Blood glucose level rises.

Liver breaks down glycogen and releases glucose into the blood.

Alpha cells of pancreas release glucagon into the blood. Glucagon

Glucose transporters.
Transporter Tissues Glucose Km (mmol/ L) 1-2 Function

GLUT 1

All tissues, especially red cells, brain B cells of pancreas; liver, kidney; gut Brain, kidney, placenta, other tissues Muscle, adipose Gut, kidney

Basal uptake of glucose; transport across the bloodbrain barrier Regulation of insulin release, other aspects of glucose homeostasis Uptake into neurons, other tissues Insulin-mediated uptake of glucose Absorption of fructose

GLUT 2

15-20

GLUT 3

<1 5 1-2

GLUT 4 GLUT 5