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    Pharmacology in Drug Discovery and Development: Understanding Drug Response
    Unavailable
    Pharmacology in Drug Discovery and Development: Understanding Drug Response
    Unavailable
    Pharmacology in Drug Discovery and Development: Understanding Drug Response
    Ebook698 pages6 hours

    Pharmacology in Drug Discovery and Development: Understanding Drug Response

    By Terry P. Kenakin

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    Currently unavailable

    About this ebook

    Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development.

    Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization.

    This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.

    • Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further research
    • Provides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout history
    • Offers sample questions throughout the book and an appendix containing answers for self-testing and retention
    LanguageEnglish
    PublisherAcademic Press
    Release dateOct 21, 2016
    ISBN9780128037539
    Unavailable
    Pharmacology in Drug Discovery and Development: Understanding Drug Response
    Author

    Terry P. Kenakin

    Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

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