Ion Channels and Disease
()
About this ebook
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.
Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.
This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.
- Introduces the relevant aspects of molecular biology and biophysics
- Describes the principal methods used to study channelopathies
- Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function
- Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Frances M. Ashcroft
Dr. Frances Ashcroft is a Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology and a Fellow of Trinity College at the University of Oxford. Elected a Fellow of the Royal Society of London in 1999, she wrote the previous edition of Ion Channels and Disease and is Director of both the Oxford Centre for Gene Function and OXION, a training and research program on the integrative physiology of ion channels. In addition to being elected a Fellow of the Royal Society in 1999, Dr. Ashcroft was also awarded the Walter B. Cannon Award, the highest honor bestowed by the American Physiological Society, and the 2012 L'Oréal-UNESCO Award for Women in Science. She was awarded honorary degrees of Doctor of the University from the Open University and Doctor of Science from the University of Leicester for her incredible contributions to ion channel physiology. Her current research focuses on the role of ATP-sensitive potassium channels in insulin secretion in both health and disease, aiming to decipher why this process is dysfunctional in individuals with type 2 diabetes.
Related to Ion Channels and Disease
Related ebooks
Mass Action in the Nervous System Rating: 0 out of 5 stars0 ratingsLight and Electron Microscopy of Cells and Tissues Rating: 0 out of 5 stars0 ratingsBiochemical and Structural Dynamics of the Cell Nucleus Rating: 0 out of 5 stars0 ratingsStructural and Evolutionary Genomics: Natural Selection in Genome Evolution Rating: 5 out of 5 stars5/5The Inductive Brain in Development and Evolution Rating: 0 out of 5 stars0 ratingsDevelopmental and Cellular Skeletal Biology Rating: 0 out of 5 stars0 ratingsNeural Crest Cells: Evolution, Development and Disease Rating: 0 out of 5 stars0 ratingsNuclear Architecture and Dynamics Rating: 0 out of 5 stars0 ratingsThe How and the Why Rating: 2 out of 5 stars2/5History of Medical Miracles and the Lives Behind Them Rating: 0 out of 5 stars0 ratingsHistone Modifications in Therapy Rating: 0 out of 5 stars0 ratingsEpigenetic Technological Applications Rating: 0 out of 5 stars0 ratingsAmphioxus Immunity: Tracing the Origins of Human Immunity Rating: 0 out of 5 stars0 ratingsThe Large-Scale Structure of the Universe Rating: 4 out of 5 stars4/5Cell Surface Receptors Rating: 0 out of 5 stars0 ratingsA New Look at Mechanisms in Bioenergetics Rating: 0 out of 5 stars0 ratingsAdvances in Radiation Biology V14: Relative Radiation Sensitivities of Human Organ Systems. Part II Rating: 0 out of 5 stars0 ratingsPrecision Radiation Oncology Rating: 0 out of 5 stars0 ratingsIon Channels in Health and Disease Rating: 0 out of 5 stars0 ratingsHistorical epistemology and the making of modern Chinese medicine Rating: 0 out of 5 stars0 ratingsPerinatal and Developmental Epigenetics Rating: 0 out of 5 stars0 ratingsThe Biology of Cancer Rating: 0 out of 5 stars0 ratingsThe Cell Cycle: Gene-Enzyme Interactions Rating: 0 out of 5 stars0 ratingsTransplantation at a Glance Rating: 0 out of 5 stars0 ratingsFluid Environment of the Brain Rating: 0 out of 5 stars0 ratingsBuilding the Most Complex Structure on Earth: An Epigenetic Narrative of Development and Evolution of Animals Rating: 0 out of 5 stars0 ratingsA Simple Guide to Variant Creutzfeldt-Jakob Disease, Diagnosis, Treatment and Related Conditions Rating: 0 out of 5 stars0 ratingsSomatic Genome Variation: in Animals, Plants, and Microorganisms Rating: 0 out of 5 stars0 ratingsOptima for Animals: Revised Edition Rating: 4 out of 5 stars4/5
Biology For You
Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5"Cause Unknown": The Epidemic of Sudden Deaths in 2021 & 2022 Rating: 5 out of 5 stars5/5Why We Sleep: Unlocking the Power of Sleep and Dreams Rating: 4 out of 5 stars4/5The Soul of an Octopus: A Surprising Exploration into the Wonder of Consciousness Rating: 4 out of 5 stars4/5The Grieving Brain: The Surprising Science of How We Learn from Love and Loss Rating: 4 out of 5 stars4/5A Letter to Liberals: Censorship and COVID: An Attack on Science and American Ideals Rating: 3 out of 5 stars3/5The Sixth Extinction: An Unnatural History Rating: 4 out of 5 stars4/5Sapiens: A Brief History of Humankind Rating: 4 out of 5 stars4/5All That Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes Rating: 4 out of 5 stars4/5Mother of God: An Extraordinary Journey into the Uncharted Tributaries of the Western Amazon Rating: 4 out of 5 stars4/5Lifespan: Why We Age—and Why We Don't Have To Rating: 4 out of 5 stars4/5The Winner Effect: The Neuroscience of Success and Failure Rating: 5 out of 5 stars5/5How Emotions Are Made: The Secret Life of the Brain Rating: 4 out of 5 stars4/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness Rating: 4 out of 5 stars4/5Anatomy 101: From Muscles and Bones to Organs and Systems, Your Guide to How the Human Body Works Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career Rating: 4 out of 5 stars4/5Dopamine Detox: Biohacking Your Way To Better Focus, Greater Happiness, and Peak Performance Rating: 3 out of 5 stars3/5The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race Rating: 4 out of 5 stars4/5Suicidal: Why We Kill Ourselves Rating: 4 out of 5 stars4/5Lies My Gov't Told Me: And the Better Future Coming Rating: 4 out of 5 stars4/5The Blood of Emmett Till Rating: 4 out of 5 stars4/5The Trouble With Testosterone: And Other Essays On The Biology Of The Human Predi Rating: 4 out of 5 stars4/5The Obesity Code: the bestselling guide to unlocking the secrets of weight loss Rating: 4 out of 5 stars4/5Jaws: The Story of a Hidden Epidemic Rating: 4 out of 5 stars4/5A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution Rating: 4 out of 5 stars4/5Homo Deus: A Brief History of Tomorrow Rating: 4 out of 5 stars4/5Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-First Century Rating: 4 out of 5 stars4/5
Reviews for Ion Channels and Disease
0 ratings0 reviews