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Moises Auron, MD, FAAP, FACP Assistant Professor of Medicine and Pediatrics
Outline
Anemia Physiology Current evidence for transfusion medicine Adverse effects of blood utilization
It is right to say
The safest transfusion is the one that is avoided The best transfusion is the one that is avoided
What is the evidence? What is the comparison?
Physiology
Pre-load After-load Contractility Stroke volume (SV)
SV x Heart rate = Cardiac output (CO) CaO2 = SaO2 x 1.34 x Hb + [PaO2 x 0.003] DO2 = CO x CaO2 O2ER = VO2/DO2 (~20-30%) DO2crit = < 7.3 ml O2/kg/min
Madjdpour C, et al. Crit Care Med 2006; 34[Suppl.]:S102S108.
Physiology
Outline
Anemia Physiology Current evidence for transfusion medicine Adverse effects of blood utilization
N = 5065 4804 were not transfused before surgery Hb < 11 increase in postop adverse effects (renal, CNS (P=0.001)) Specially in patients with EUROSCORE > 4 Circulation. 2007;116: 471-479. http://www.euroscore.org
N = 1,136,201 1996-1997
N = 227 425 patients (69 229 preoperatory anemia) Postoperative mortality (30 days) (OR 1.42, 95% CI 1.31-1.54) - Mild Anemia (OR 1.41, 1.30-1.53) - Moderate-severe Anemia (OR 1.44, 1.29-1.60) Postoperative morbidity (30 days) (OR 1.35, 1.30-1.40) - Mild Anemia (OR 1.31, 1.26-1.36) - Moderate-severe Anemia (1.56, 1.47-1.66)
Carson JL, et al. Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Int Med 2012.
- Hemoglobin 131.3 to 9.31 g/dl - No left ventricle dysfunction or hemodynamic instability. Crit Care Med. 2005 Mar;33(3):591-7.
Hb 9.1 g/dL Increase C.I, C.O, and pre-load indexes - Less viscosity increases venous return, pre-load increase stroke voume - Consider in patients with preserved LV function
Anaesthesia, 2004;59:11701177.
Anaesthesia, 1998;53:20-24.
N = 20 Age +/- S.E.M. = 76 y/o (66-85) Excluded: Hx of CAD, valvular cardiomyopathy, non-sinus rhythm, LBBB, betablocker use, Hb < 10 g/dL.
Isovolumetric hemodilution was well tolerated in elderly down to 8.8 +/- 0.3 g/dL
Anesth Analg 1996;82:681-6.
Horizontal addition
Immediate memory
There is no difference between time of reaction (speed and precision of processing information) or in immediate Delayed memory Numeric substitution and delayed memory between Hemoglobin of 7 g/dL vs. 14 g/dL.
Anesthesiology. 2000;92:1646-52.
There is no difference in reaction time in patients with Hemoglobin of 5.7 g/dL who used supplemental O2 (PaO2 > 350 mm Hg equals to increase Hb ~ 2-3 g/dL reverse effects of acute anemia
N = 31 healthy volunteers (28 y/o +/- 4) Tests: verbal and standard memory; computerized neuropsychological Basal hemoglobin 12.7 g/dL hemodilution to 5.7 g/dL
Habler O, et al. Eur J Med Res 1997;2:419424. Meier J, et al. Clin Physiol Funct Imaging 2005; 25: 158-65.
TRICC Study N = 838 Hb < 9.0 g/dL Euvolemic Restrictive Hb < 7 g/dL (N = 418) Liberal Hb < 10 g/dL (N = 420)
NEJM 1999;340(6):409-17.
TRIPICU Study (non-inferiority) N = 637 hemodinamically stable children 320 Transfused for Hb < 7.0 g/dL 317 Transfused for Hb < 9.5 g/dL No significant difference in prognostic markers (death, infections, inpatient stay in ICU).
Complication Inpatient mortality Mortality at 1 year Prolonged intubation (>72h) Renal failure Sepsis
P 0.004 0.001
Holme S. Transfus Apher Sci 2005;33:5561. Hovav T, et al. Transfusion 1999; 39(3):277-81.
Hb Limit (g/dL) 6
7 7 8 7 7
Murphy MF, et al. Br J Haematol. 2001;113:24-31. Bassand JP, et al. Eur Heart J. 2007;28:1598-660. Carson JL, et al. Ann Int Med 2012 (online first).
Transfusion restrictive strategy Critical patients consider transfusion if Hb < 7 g/dL Post-op surgical patients - consider transfusion if Hb < 8 g/dL or if symptomatic (angina; orthostatic hypotension; tachycardia refractory to IVF resuscitation, CHF)
Carson JL, et al. Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Int Med 2012.
Outline
Anemia Physiology Current evidence for transfusion medicine Adverse effects of blood utilization
Carson JL, et al. Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB. Ann Int Med 2012.